HCID 70575102, compound → HCID 70574322, compound

Participants

Reaction Steps

Under a hydrogen pressure of 3.2 kg/cm2 and in the presence of 4 g of palladium on carbon (10% Pd), a solution of benzyl 1'-benzyl-6-(2-phenylacetamido)-spiro[penam-2,4'-piperidine]-3-carboxylate (prepared in I.2.a) in 800 ml of ethanol is hydrogenolyzed in a Parr's apparatus for 1,5 hours, then filtered and the filtrate is evaporated to dryness in a vacuum and the residue is triturated in isopropyl alcohol. 1'-Benzyl-6-(2-phenylacetamido)-spiro[penam-2,4'-piperidine]-3-carboxylic acid is thus obtained in a yield of 71%; M.P. 170°-171° C. (decomposition).

Provenance & Evidence