p-Toluenesulfonic acid → HCID 86737764, compound

Participants

Reaction Steps

A mixture of 16 g (0.0266 mole) of benzyl 1'-methyl-6-tritylamino-spiro-[pename-2,4'-piperidine]-3-carboxylate (obtained in 7.1) and of 10.12 g (0.053 mole) of p-toluene-sulfonic acid is stirred for four hours at ambient temperature in 160 ml of acetone. After filtration and drying, 15 g (79.9% yield) of benzyl 6-amino-1'-methyl-spiro[penam-2,4'-piperidine]-3-carboxylate di-p-toluenesulfonate are obtained; M.P. 182°-183° C.

Provenance & Evidence