Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Benzoic acid, 4-[[(4-chlorophenyl)methyl]amino]-, ethyl ester | HCID 773384 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 23458905 | HCID 23458905 | 80% |
Reaction Steps
To ethyl-4-(4-chlorobenzylamino)-benzoate (5.8 g; 0.02 mole) was added 80% formic acid (30 ml) and 40% formaldehyde solution (10 ml) and the mixture was heated at 100° C. for 6 hours. The reaction mixture was cooled to room temperature, water (60 ml) added and the product filtered, dried under vacuum at 60° C. and was crystallised from ethanol to give N-(4-ethoxycarbonylphenyl)-N-(4-chlorobenzyl)-methylamine (4.86 g; 80%). M.p. 106°-7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04271188 |
|---|
| Source dataset | uspto-grants-1981_06 |
|---|
| ORD ID | ord-653756adbd76431096380154a3a13c51 |
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| Source note | uspto-grants-1981_06 |
|---|
