Benzhydrol → HCID 23459080, compound

Participants

Reaction Steps

Diphenylmethanol (18.4 g, 0.1 m) was added portionwise to a suspension of sodium hydride (2.4 g, 0.1 m) in dimethylformamide (300 ml) under nitrogen. After the reaction had ceased, the suspension was treated dropwise with a solution of 4-nitropyridine-1-oxide (14 g, 0.1 m) in dimethylformamide (500 ml). This caused the colour of the mixture to change from orange to dark blue. After a further twelve hours at room temperature, the mixture was filtered and evaporated under reduced pressure, leaving a residue that crystallised from toluene giving 19.8 g of 4-[diphenylmethoxy]pyridine-1-oxide as light yellow crystals, m.pt. 155°-157° C.

Provenance & Evidence