Phthalic Anhydride → 1-(2-Carboxybenzoyl)-2-methyl-4-phenyl-3-thiosemicarbazide

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Reaction Steps

2-Methyl-4-phenyl-3-thiosemicarbazide (0.2 mole) was dissolved in 75 ml of dimethylformamide and placed in a 3-necked round-bottomed flask equipped with magnetic stirrer, condenser, additional powder funnel and thermometer. Phthalic anhydride (0.2 mole) was added in portions at 20°. The contents were stirred overnight at room temperature, then poured into ice water. The resulting solid product was recrystallized from a mixture of hexane and ethanol.

Provenance & Evidence