p-Toluenesulfonic acid → HCID 12800131, compound

Participants

Reaction Steps

Androstenedione (10 g.) was dissolved in propan-2-ol (500 ml). Triethyl orthoformate (7.15 ml) was added, followed by p-toluenesulphonic acid (250 mg) and the solution refluxed for fifteen minutes. A few drops of pyridine were added and the solution evaporated under reduced pressure to give a pale yellow solid. This was recrystallised from methanol to give 3-iso-propoxy-androsta-3,5-dien-17-one (8.0 g) as white crystals, M.p. 147°-151°. ##STR14##

Provenance & Evidence