Androstenedione → 3-Ethoxy-androsta-3,5-dien-17-one

HRID 1680134Notes

Reaction equation

HRID 1680134 reaction equation
[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH2:8][CH2:9][C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[CH:11]=4)[C@@H:6]1[CH2:5][CH2:4][C:3]2=[O:21].C([O-])([O-])O[CH2:24][CH3:25]>>[CH2:24]([O:20][C:12]1[CH2:13][CH2:14][C@@:15]2([CH3:16])[C:10](=[CH:9][CH2:8][C@@H:7]3[C@@H:17]2[CH2:18][CH2:19][C@@:2]2([CH3:1])[C@H:6]3[CH2:5][CH2:4][C:3]2=[O:21])[CH:11]=1)[CH3:25]

Participants

3

Reactant 2

HCID 6128AndrostenedioneHCID 53630039Ethylorthoformate

Product 1

HCID 103582913-Ethoxy-androsta-3,5-dien-17-one

Procedure

The process according to claim 1 wherein androst-4-en-3,17-dione is treated with ethyl orthoformate to yield 3-ethoxyandrosta-3,5(6)-dien-17-one.

Sources & evidence

ORD record
ord-66d5e7373b474fa7b958e1c8307fd624
Source dataset
uspto-grants-1981_06
Patent number
US04272445

Reaction notes

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