Water → HCID 23457196, compound

Participants

Reaction Steps

26.3 g (0.1 mole) of 4-(3-chloro-2-methylanilino)-3-thiophenacetonitrile are introduced into 135 ml of concentrated sulfuric acid; the resulting mixture is stirred at 20° for 1 hour; 49 ml of water are then added dropwise and the obtained mixture is heated to 100° for 3 hours. It is poured onto ice, and the precipitate, which has formed, is filtered off. Recrystallization from diisopropyl ether gives 4-(3-chloro-2-methylanilino)-3-thiophenacetic acid. m. 126° to 128°.

Provenance & Evidence