Sodium Cyanide → HCID 23457241, compound

Participants

Reaction Steps

2.72 g (10 mmoles) of 3-chloromethyl-4-(2-chloro-3-methylanilino)thiophen in 15 ml of dimethylsulfoxide are added dropwise to a solution of 650 mg of sodium cyanide in 15 ml of dimethylsulfoxide at 40°. The mixture is stirred for a further three hours, poured onto water and extracted three times with ethyl acetate. The combined extracts are washed with 50 ml each of 6 N hydrochloric acid and water, dried and concentrated. Crude 4-(2-chloro-3-methylanilino)-3-thiophenacetonitrile is obtained as an oil.

Provenance & Evidence