反应详情

3.16 g (10 mmoles) of 3-(2,6-dichloroanilino)-2-thiophenglyoxylic acid and 2 g of sodium boranate are warmed to 80° in 10 ml of dimethylformamide for 4 hours. The mixture is poured onto water and extracted with toluene, the aqueous phase is acidified and extracted with ethyl acetate, and the organic phase is dried and concentrated. Recrystallization of the residue from toluene yields 3-(2,6-dichloroanilino)-2-thiophenacetic acid (m. 164° to 168°).

1. additionThe mixture is poured onto water
2. extractionextracted with toluene
3. extractionextracted with ethyl acetate
4. customthe organic phase is dried
5. concentrationconcentrated
6. customRecrystallization of the residue from toluene