Sodium metaborate → HCID 23457180, 화합물

HRID 1680159노트

반응식

HRID 1680159 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:3]=1[NH:4][C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10](=O)[C:11]([OH:13])=[O:12].B([O-])=O.[Na+]>CN(C)C=O>[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:3]=1[NH:4][C:5]1[CH:9]=[CH:8][S:7][C:6]=1[CH2:10][C:11]([OH:13])=[O:12]

참가 물질

4

반응물 2

HCID 145326Sodium metaborateHCID 705740963-(2,6-Dichloroanilino)-2-thiophenglyoxylic acid

생성물 1

HCID 23457180HCID 23457180, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3.16 g (10 mmoles) of 3-(2,6-dichloroanilino)-2-thiophenglyoxylic acid and 2 g of sodium boranate are warmed to 80° in 10 ml of dimethylformamide for 4 hours. The mixture is poured onto water and extracted with toluene, the aqueous phase is acidified and extracted with ethyl acetate, and the organic phase is dried and concentrated. Recrystallization of the residue from toluene yields 3-(2,6-dichloroanilino)-2-thiophenacetic acid (m. 164° to 168°).

후처리

  1. additionThe mixture is poured onto water
  2. extractionextracted with toluene
  3. extractionextracted with ethyl acetate
  4. customthe organic phase is dried
  5. concentrationconcentrated
  6. customRecrystallization of the residue from toluene

출처 및 근거

ORD 기록
ord-dae3550d4c7c4d11820f47cf04ec59f9
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04272507

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