HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(2,6-Dichloroanilino)-2-thiophenglyoxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethoxalyl chloride | HCID 20884 | — |
| Reactant | 3-(2,6-Dichloroanilino)thiophen | HCID 23457223 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2,6-Dichloroanilino)-2-thiophenglyoxylic acid ethyl ester | HCID 70576059 | — |
Reaction Steps
2.44 g (10 mmoles) of 3-(2,6-dichloroanilino)thiophen, 1.01 g of triethylamine and 1.37 g (10 mmoles) of chlorooxalic acid ethyl ester are stirred in 20 ml of tetrahydrofuran at room temperature for 10 hours. 100 ml each of water and ethyl acetate are added, and the organic phase is dried and concentrated. Recrystallization of the residue from ethanol gives 3-(2,6-dichloroanilino)-2-thiophenglyoxylic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04272507 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-82acdef777024c0cbb806856f3439b3d |
| Source note | uspto-grants-1981_06 |