反应详情

330 mg (1 mmole) of 3-(2,6-dichloroanilino)-2-thiophenacetic acid ethyl ester are boiled with 1 g of potassium hydroxide in 5 ml of ethanol for one hour. The mixture is then diluted with 20 ml of water and extracted with 20 ml of methylene chloride. The aqueous solution is acidified, and the precipitate which has formed is filtered off and washed with 3 ml of diisopropyl ether. 3-(2,6-Dichloroanilino)-2-thiophenacetic acid (m. 164° to 168°) is obtained.

1. extractionextracted with 20 ml of methylene chloride
2. customthe precipitate which has formed
3. filtrationis filtered off
4. washwashed with 3 ml of diisopropyl ether