Water → Eltenac

HRID 1680167Notes

Reaction equation

HRID 1680167 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][C:11](N)=[O:12])=[CH:7][S:8][CH:9]=1.[OH2:19]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][C:11]([OH:19])=[O:12])=[CH:7][S:8][CH:9]=1

Participants

4

Reactant 2

HCID 962WaterHCID 23457236HCID 23457236, compound

Product 1

HCID 51717Eltenac

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

30.1 g (0.1 mole) of 4-(2,6-dichloroanilino)-3-thiophenacetamide are warmed to 100° in 135 ml of concentrated sulfuric acid and 49 ml of water for 3 hours. The mixture is poured onto ice, and the precipitate of 4-(2,6-dichloroanilino)-3-thiophenacetic acid which has formed in filtered off. The precipitate is boiled up with diisopropyl ether and dried; it then melts at 179° to 180°.

Workup

  1. additionThe mixture is poured onto ice

Sources & evidence

ORD record
ord-14cf263212bc43c69a5aa83dcd34dc40
Source dataset
uspto-grants-1981_06
Patent number
US04272507

Reaction notes

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