2-(2-Pyridiniomethyl)isothiouronium dichloride → Thiourea

HRID 1680196Notes

Reaction equation

HRID 1680196 reaction equation
[ClH:1].Cl.[CH3:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][S:11][C:12](=[NH:14])[NH2:13])=[N:8][CH:9]=1.Cl.Cl.N1C=CC=CC=1CSC(=N)N>>[ClH:1].[Cl:1][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([CH3:3])=[CH:9][N:8]=1.[NH2:13][C:12]([NH2:14])=[S:11].[ClH:1].[ClH:1].[CH3:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][S:11][C:12](=[NH:13])[NH2:14])=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 130439522-(2-Pyridiniomethyl)isothiouronium dichlorideHCID 23457323HCID 23457323, compound

Product 3

HCID 2723790ThioureaHCID 233137952-(Chloromethyl)-5-methylpyridine hydrochlorideHCID 23457323HCID 23457323, compound

Procedure

2-(5-Methylpyrid-2-ylmethyl)isothiourea dihydrochloride can be prepared in accordance with the method described in Example 1 for the preparation of 2-(pyrid-2-ylmethyl)isothiourea dihydrochloride. Using 2-chloromethyl-5-methylpyridine hydrochloride (170 g) and thiourea (86 g) as the starting materials, 2-(5-methylpyrid-2-ylmethyl)isothiourea dihydrochloride (160 g) is obtained.

Sources & evidence

ORD record
ord-b87187e41bf4488396b292389ba02e72
Source dataset
uspto-grants-1981_06
Patent number
US04272534

Reaction notes

Loading…