Hydrochloric Acid → HCID 178430736, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3,5-diamino-6-chloro-N-(3,4-dihydro-4,4-dimethyl-6-ethoxy-1,3,5-triazin-2-yl)-2-pyrazinecarboxamide (0.55 g., 0.0016 mole) in sulfolane (10 ml.) is added trimethylsilyl iodide (1.5 ml.). The reaction mixture is stirred for 5 hours at 45° C., poured into ice water (30 ml.) containing hydrochloric acid (1.5 ml.), then extracted with chloroform (2×15 ml.) The aqueous layer is made basic with ammonia to give 420 mg. of 3,5-diamino-6-chloro-N-(3,4-dihydro-4,4-dimethyl-6-hydroxy-1,3,5-triazin-2-yl)-2-pyrazinecarboxamide which melts at 266°-8° C. after reprecipitation from dilute hydrochloric acid with ammonia.

Provenance & Evidence