4-Methylcyclohexanone → Pyrazinamide

Participants

Reaction Steps

A solution of 3,5-diamino-6-chloro-N-[[(aminocarbonyl)amino]iminomethyl]-2-pyrazinecarboxamide (0.5 g., 0.0018 mole) and 4-methylcyclohexanone (0.5 ml.) in dimethylformamide (10 ml.) is heated at 95° C. for 20 hours. The reaction mixture is treated with 20 ml. of 2-propanol, filtered, the filtrate distilled at reduced pressure to a volume of 2 ml. and chromatographed on silica gel to give 3,5-diamino-6-chloro-N-(3',4'-dihydro-6'-hydroxy-4-methylspirocyclohexane]1,4']-1,3,5-triazin-2-yl)-2-pyrazinecarboxamide which melts at 274° C.

Provenance & Evidence