反应详情

1-[2-Hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole (2.0 g) in thionyl chloride (10 ml) is warmed for one hour at 65°. The excess thionyl chloride is removed in vacuo, the residue dissolved in dichloromethane (75 ml) and shaken with excess aqueous potassium carbonate. The organic layer is washed with water, dried over MgSO4, evaporated and the residue evacuated to remove all traces of dichloromethane, affording 1-[2-chloro-4-(4-chlorophenyl)-n-butyl]imidazole.

1. customThe excess thionyl chloride is removed in vacuo
2. dissolutionthe residue dissolved in dichloromethane (75 ml)
3. washThe organic layer is washed with water
4. dry with materialdried over MgSO4
5. customevaporated
6. customthe residue evacuated
7. customto remove all traces of dichloromethane