HCID 56990704, compound → HCID 57235184, compound

Participants

Reaction Steps

7,8-Didehydro-3,14-dimethoxy-4,5-epoxy-17-methylmorphinan-6-one (14) (5.0 g, 15.27 mmol) was hydrogenated in methanol (75 ml) over 500 mg Pd/charcoal (10%) at 3 atm. After filration through Celite the solvent was removed under reduced pressure to afford 4.92 g (98% theory) of a white solid 15, mp 140°-142° C. Recrystallization from ethanol gave 4.52 g (90% theory) of 15 as a white solid, mp 146°-146.5° C.

Provenance & Evidence