Ammonium Chloride → HCID 86737785, compound

Participants

Reaction Steps

A mixture of 15 (1.67 g), Zn dust (0.72 g), ammonium chloride (1.1 g) and ethanol (45 ml) was refluxed for 6 hour under N2 atmosphere. The product was filtered and the residual solid washed with ethanol. The filtrate was concentrated under reduced pressure to give the hydrochloride salt of 16 as a white solid (2.71 g). This product contained some ammonium chloride but was used without purification in the next reaction. Attempts to purify the material by preparation of the free base resulted in loss of material.

Provenance & Evidence