Hydrochloric Acid → HCID 86737788, compound

Participants

Reaction Steps

A mixture of 3-hydroxy-14-methoxy-8α methylmorphinan-6-one (27) (0.13 g, 0.43 mmol), dimethylallyl bromide (0.125 g, 0.84 mmol) and ethanol (10 ml) was refluxed under a nitrogen atmosphere for 16 hours (oil bath temperature 105°-110° C). The mixture was filtered and the residue washed with ethanol. The filtrate upon concentration gave a solid product which was chromatographed over silica gel using graded methanol/chroloform mixtures as the eluant. Fractions containing the desired product were collected and evaporated to give total of 0.02 g (12.6% theory) of pure product. An additional 0.026 g of less pure 28 was also obtained. The pure material was converted into the HCl salt by treatment with ethereal HCl.

Provenance & Evidence