Cyanogen Bromide → HCID 86737790, compound

Participants

Reaction Steps

A slurry of 3,14-dimethoxy-8β,17-dimethylmorphinan-6-one (35) (4.4 g, 0.0134 mol), cyanogen bromide (4.2 g, 0.04 mol), and anhydrous potassium carbonate (5.5 g, 0.04 mol) in 140 ml of methylene chlordie was heated at reflux temperature for 22 hours under a nitrogen atmosphere. The potassium carbonate was removed by suction filtration and the filter cake washed throughly with methylene chloride. The solvent was removed from the filtrate under reduced pressure to leave 4.1 g (90% theory) of the title compound which was used in the next reaction step without further purification.

Provenance & Evidence