Sodium Bicarbonate → HCID 86737784, compound

Participants

Reaction Steps

Prepared by reaction of 18a (3.70 g, 12.3 mmole) with cyclobutylmethyl bromide (2.24 g, 14.7 mmole) in the presence of NaHCO3 (2.00 g, 25 mmole) in DMF (50 ml) at 100° under argon for 6 hours to give, after processing in the usual manner, 4.50 g (99%) of 19a-CBM as a foam. NMR: δ 6.60; 2H, s (aromatic); 5.5, 1H, broad (hydroxyl), 4.24, 1H, d (H-5α, J=13 Hz); 3.76 (CH3O--), 0.86, 3H, d(7α-CH3, J=6.5 Hz).

Provenance & Evidence