Sodium Hydroxide → HCID 12898556, compound

Participants

Reaction Steps

To N-benzyl-2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenoxy]acetamide (3.0 g=6.0 mmol) in 75 ml toluene add sodium bis-2-methoxyethoxy)aluminum hydride (70% solution in benzene, 8.0 g=28 mmol) over 1/2 hour. Stir 16 hours, treat with 1.0 N NaOH, and extract with ethyl acetate. Dry and concentrate the organic layer. Recrystallize from ether-hexane to give 2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenoxy]ethylbenzylamine, as white crystals, m.p. 117°-120° C.

Provenance & Evidence