Acetic Anhydride → HCID 53964927, compound

HRID 1680270Notes

Reaction equation

HRID 1680270 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[C:13]2[C:8](=[CH:9][C:10]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:11]([OH:14])[CH:12]=2)[CH2:7][CH2:6]1)=[O:4].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[CH3:1][O:2][C:3]([CH:5]1[C:13]2[C:8](=[CH:9][C:10]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:11]([O:14][C:23](=[O:25])[CH3:24])[CH:12]=2)[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 54109752HCID 54109752, compound

Product 1

HCID 53964927HCID 53964927, compound

Procedure

A solution of 10 g of 5-benzoyl-6-hydroxy-indane-1-carboxylic acid methyl ester in 100 ml of acetic anhydride is heated to the reflux temperature for 4 hours under anhydrous conditions. It is then evaporated to dryness in vacuo. The evaporation residue is mixed with 200 ml of toluene and evaporated in vacuo. Distillation of the evaporation residue in a high vacuum gives, in the fraction boiling at 195°-200° C./0.06 mm Hg, 5-benzoyl-6-acetoxy-indane-1-carboxylic acid methyl ester in the form of a colourless oil.

Workup

  1. customIt is then evaporated to dryness in vacuo
  2. additionThe evaporation residue is mixed with 200 ml of toluene
  3. customevaporated in vacuo
  4. distillationDistillation of the evaporation residue in a high vacuum

Sources & evidence

ORD record
ord-835c95af56274dcab7a2930d96b82be7
Source dataset
uspto-grants-1981_06
Patent number
US04272547

Reaction notes

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