Methanol → HCID 54313851, compound

HRID 1680272Notes

Reaction equation

HRID 1680272 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[C:6]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][C:16]=1[OH:17])[CH:13]([C:18]([OH:20])=[O:19])[CH2:12][CH2:11]2)=[O:7].[CH3:25]O>>[CH3:25][O:19][C:18]([CH:13]1[C:14]2[C:10](=[CH:9][C:8]([C:6](=[O:7])[C:5]3[CH:21]=[CH:22][CH:23]=[CH:24][C:4]=3[Cl:3])=[C:16]([OH:17])[CH:15]=2)[CH2:11][CH2:12]1)=[O:20]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 23457896HCID 23457896, compound

Product 1

HCID 54313851HCID 54313851, compound

Procedure

Analogously to the description in Example 2, 8.7 g of 5-(o-chlorobenzoyl)-6-hydroxy-indane-1-carboxylic acid methyl ester and 27 ml of 2 N sodium hydroxide solution in 100 ml of methanol give 5-(o-chlorobenzoyl)-6-hydroxy-indane-1-carboxylic acid of melting point 188°-190° C. (from ethyl acetate-petroleum ether).

Sources & evidence

ORD record
ord-d2ff25fea94449c0bc99d1ca40a0701a
Source dataset
uspto-grants-1981_06
Patent number
US04272547

Reaction notes

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