HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → p-Nitrobenzyl 2-(4-Acetylthio-2-oxo-1-azetidinyl)-2-chloroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | p-Nitrobenzyl 2-(4-acetylthio-2-oxo-1-azetidinyl)-2-hydroxyacetate | HCID 13132061 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | p-Nitrobenzyl 2-(4-Acetylthio-2-oxo-1-azetidinyl)-2-chloroacetate | HCID 13132062 | 99% |
Reaction Steps
A solution of acid 1 (19.36 g), thionyl chloride (40 ml) and dichloromethane (200 ml) was stirred at 23° for 18 h. The solvent and excess thionyl chloride were evaporated in vacuo at 23° to give acid chloride 2 as an off-white solid, 20.5 g (99% yield). ##STR123##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04272437 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-ffa8268d9854461896c907dc44f8e3ac |
| Source note | uspto-grants-1981_06 |