Cinnamaldehyde → HCID 53986343, compound

HRID 1680439Notes

Reaction equation

HRID 1680439 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][N:6]=1)=[O:4].[CH:12](=O)/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]=[CH:12][CH:13]=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 637511CinnamaldehydeHCID 12457877Methyl 5-aminopyridine-2-carboxylate

Product 1

HCID 53986343HCID 53986343, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The starting material is prepared as follows: The mixture of 7.61 g of 5-amino-pyridine-2-carboxylic acid methyl ester, 7.61 g of trans-cinnamaldehyde and 130 ml of benzene is stirred and refluxed on a water trap for 41/2 hours. It is evaporated and the residue recrystallized from ethyl acetate, to yield the 5-cinnamylideneaminopyridine-2-carboxylic acid methyl ester melting at 128°-131°.

Workup

  1. customThe starting material is prepared
  2. temperaturerefluxed on a water trap for 41/2 hours
  3. customIt is evaporated
  4. customthe residue recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-849922dcd8524021a9ccca82ec08d91a
Source dataset
uspto-grants-1981_06
Patent number
US04273779

Reaction notes

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