Methane → HCID 53966654, compound

Participants

Reaction Steps

To the solution of 11.9 g of 5-cinnamylamino-pyridine-2-carboxylic acid methyl ester in 25 ml of isopropanol, 28 ml of 2 N aqueous sodium hydroxide are added and the mixture intermittently heated on the steam bath for 40 minutes. It is cooled, decolorized with charcoal, filtered and the filtrate slightly acidified with hydrochloric acid and acetic acid. The mixture is extracted with benzene, the extract dried, evaporated and the residue recrystallized from benzene/methanol, to yield the 5-cinnamylaminopyridine-2-carboxylic acid melting at 178°-183°.

Provenance & Evidence