HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 5-Benzylideneaminopyridine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Benzene | HCID 241 | — |
| Reactant | Methyl 5-aminopyridine-2-carboxylate | HCID 12457877 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Benzylideneaminopyridine-2-carboxylic acid methyl ester | HCID 53671695 | — |
Reaction Steps
The starting material is prepared as follows: The mixture of 17.4 g of 5-aminopyridine-2-carboxylic acid methyl ester, 14.0 g of benzaldehyde and 100 ml of benzene is stirred and refluxed on a water separator for 6.5 hours. The resulting clear solution is evaporated, and the residue recrystallized from benzene-hexane first, then from acetonitrile-diethyl ether, to yield the 5-benzylideneaminopyridine-2-carboxylic acid methyl ester, melting at 84°-89°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04273779 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-6a0602e10a9c43fda3eb694b3348d194 |
| Source note | uspto-grants-1981_06 |