Ethyl 4-(bromomethyl)benzoate → HCID 70575134, compound

HRID 1680477Notes

Reaction equation

HRID 1680477 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[NH:9][CH:8]=1.Br[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:22][CH:21]=1>>[CH2:29]([O:28][C:26]([C:23]1[CH:22]=[CH:21][C:20]([CH2:19][N:9]2[C:10]3[C:15](=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=3)[C:7]([CH2:6][C:2]3[NH:3][CH:4]=[CH:5][N:1]=3)=[CH:8]2)=[CH:25][CH:24]=1)=[O:27])[CH3:30]

Participants

3

Reactant 2

HCID 954261Ethyl 4-(bromomethyl)benzoateHCID 10353691HCID 10353691, compound

Product 1

HCID 70575134HCID 70575134, compound

Procedure

This compound was prepared as described in Example 4 using 3-(1-imidazolylmethyl)-5-methoxyindole and ethyl (α-bromo-p-toluate) as starting materials. The fumarate salt hemihydrate had m.p. 113°-114° C. Found: C, 63.10; H, 5.29; N, 7.82. C23H23N3O3.C4H4O4.1/2H2O requires: C, 63.02; H, 5.48; N, 8.16%.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e56490ba1e3e4c49acda97b105eab653
Source dataset
uspto-grants-1981_06
Patent number
US04273782

Reaction notes

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