Acetic Anhydride → HCID 70575004, compound

Participants

Reaction Steps

Acetic anhydride (0.20 g) was added dropwise to a stirred solution of 1-(2-aminoethyl)-3-(1-imidazolylmethyl)indole (0.48 g) in dry chloroform (10 ml) at room temperature. The solution was stirred for 10 minutes and then evaporated. The residue was stirred with aqueous sodium bicarbonate solution and the solid product was filtered off, washed with water, dried and crystallised from ethyl acetate/petrol (b.p. 60°-80° C.) to give 1-(2-acetylaminoethyl)-3-(1-imidazolylmethyl)indole (0.26 g), m.p. 126°-128° C. Found: C, 68.08; H, 6.43; N, 20.17. C16H18N4O requires: C, 68.06; H, 6.43; N, 19.85%.

Provenance & Evidence