Ethyl chloroformate → HCID 70574908, compound

Participants

Reaction Steps

Ethyl chloroformate (0.19 g) was added dropwise to a stirred solution of 1-(2-aminoethyl)-3-(1-imidazolylmethyl)indole (0.48 g) in pyridine (5 ml) at room temperature. The solution was stirred at room temperature for 3 hours and then evaporated. The residue was stirred with aqueous sodium bicarbonate solution and the solid product was filtered off, washed with water, dried and crystallised from ethyl acetate/petrol (b.p. 60°-80° C.) to give 1-(2-methoxycarbonylaminoethyl)3-(1-imidazolylmethyl)indole (0.32 g), m.p. 78°-79° C. Found: C, 62.22; H, 5.99; N, 17.72. C16H18N4O2.1/2H2O requires: C, 62.52; H, 6.23; N, 18.23%.

Provenance & Evidence