HCID 12901715, compound → HCID 54476306, compound

Participants

Reaction Steps

3,4-Dihydropyrazino[2,1-a]isoindole-1,6(2H, 10bH)-dione (described in Example 6, 10 g, 0.049 mol) is added portionwise to a stirring mixture of 10% palladium on carbon (10 g) in 375 ml of dry toluene. The mixture is refluxed for 20 hr and filtered through Celite (diatomaceous earth). The filtrate is evaporated. The residue is chromatographed on silica gel using acetone-benzene (1:1) and the eluates are evaporated. The residue (5.0 g) is crystallized from acetone-petroleum ether to obtain 10b-phenylmethyl-3,4-dihydropyrazino[2,1-a]isoindole-1,6(2H, 10bH)-dione, mp 202°-204° C., Anal. Calc'd. for C18H16N2O2 : C, 73.95% H, 5.52% N, 9.59% and Found: C, 74.18% H, 5.72% N, 9.57%.

Provenance & Evidence