Cyclohexanecarbonyl chloride → HCID 23456604, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,4-dihydropyrazino[2,1-a]isoindole-1,6(2H, 10bH)-dione (6.0 g, 0.03 mol, described in Example 6) and cyclohexylcarbonyl chloride (6.5 g, 0.045 mol) is stirred at 120° C. for 6.5 hr and evaporated. The residue is chromatographed on silica gel using 20% acetone in benzene and the eluates are evaporated. The residue is crystallized from acetone to obtain 2-(cyclohexylcarbonyl)-1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole-1,6-dione (1.8 g), mp 167°-172° C., Anal. Calc'd. for C18H20N2O3 : C, 69.21% H, 6.45% N, 8.97% and Found: C, 69.25% H, 6.47% N, 8.93%.

Provenance & Evidence