Water → HCID 54036883, compound

Participants

Reaction Steps

A solution of N-(1,1-dimethylethoxycarbonyl)-ethylene diamine (3 g) in benzene (25 ml) is added dropwise to a solution of α,α'-dibromo-1,2-benzenediacetic acid methyl ester (3.78 g) and triethylamine (3.5 g) in benzene (75 ml). The mixture is refluxed for 18 hr using a water separator condenser and filtered. The filtrate is evaporated and the residue is chromatographed on silica gel using diethyl ether-hexane-pyridine (500:500:1). The eluate is evaporated to give the title compound (1.7 g), nmr (CDCl3) δ1.4(s), 3.03(m), 3.63(s), 5.0(s) and 7.17(m).

Provenance & Evidence