Hydrochloric Acid → HCID 12901822, compound

Participants

Reaction Steps

A mixture of 1,3-dihydro-2-[2-[N-(1,1-dimethylethoxycarbonyl)amino]ethyl]-2H-isoindole-1,3-dicarboxylic acid dimethyl ester (1.5 g, described in Example 23), 25% hydrochloric acid (3 ml) and ethyl acetate (30 ml) is refluxed for 2 hr and evaporated. Water (20 ml) is added and the solution is extracted with chloroform. The chloroform extract is evaporated and the residue is chromatographed on silica gel using methanol-chloroform (1:49). The eluate is evaporated and the residue (0.45 g) is crystallized from dichloromethane-hexane to obtain the title compound, mp 165°-167° C.

Provenance & Evidence