Water → HCID 23456565, compound

Participants

Reaction Steps

A mixture of 1,2,3,4,6,10b-hexahydro-1-oxo-pyrazino[2,1-a]isoindole-6-carboxylic acid methyl ester (0.5 g, described in Example 24) and lithium borohydride (0.044 g) in tetrahydrofuran (25 ml) is refluxed for 18 hr. Water is carefully added to decompose the excess hydride and the tetrahydrofuran is evaporated. Water is added and the solution is continuously extracted with ethyl acetate for 18 hr. The extract is dried and evaporated to give 1,2,3,4,6,10b-hexahydro-6-hydroxymethylpyrazino[2,1-a]isoindol-1-one (0.245 g), nmr (CDCl3) δ2.8(s), 3.2(m), 3.75(m), 4.3(m), 4.9(m), 6.95(s) and 7.2(m).

Provenance & Evidence