Dimethyl Sulfate → HCID 53976856, compound

Participants

Reaction Steps

A suspension of 1,3-dihydro-3-(1-nitropropyl)-isobenzofuran-1-one (53 g, described in Example 27), potassium carbonate (64 g) and dimethyl sulfate (45.4 g) in acetone (1.5 l) is stirred at room temperature for 18 hr and filtered. The filtrate is evaporated and the residue is chromatographed on silica gel using hexane-diethyl ether (4:1). The eluates are evaporated to give the title compound (49 g), nmr (CDCl3) δ1.15(t), 2.65(q), 3.94(s), 7.55(m), 8.2(m) and 8.45(s).

Provenance & Evidence