反应详情

4-Hydroxy-5,6,7,8-tetrahydro-5-hydroxyimino-3-quinolinecarboxylic acid ethyl ester (2.5 g) was suspended in 90 ml of acetic acid, and 2.6 g of zinc dust was added to the suspension with its internal temperature kept at 60° C. The resulting reaction mixture was stirred for 5 hours. After the reaction mixture was filtered to remove the insoluble matter, the filtrate was concentrated to obtain the desired compound as a crude product. This crude product was used in the succeeding Example 10 without further purification.

1. customkept at 60° C
2. customThe resulting reaction mixture
3. filtrationAfter the reaction mixture was filtered
4. customto remove the insoluble matter
5. concentrationthe filtrate was concentrated