methyl L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride → methyl L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate acetic acid salt
Reaction equation
Cl.[NH2:2][C@H:3]([C:12]([NH:14][C@@H:15]([C:20]([NH:22][CH2:23][C:24]([NH:26][C@H:27]([C:35]([CH:37]1[C:44]2([NH2:46])[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:47][C:38]1([C:48]([O:50][CH3:51])=[O:49])[CH2:39]3)[CH2:43]2)=[O:36])[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:25])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1>O>[C:48]([OH:50])(=[O:49])[CH3:38].[NH2:2][C@H:3]([C:12]([NH:14][C@@H:15]([C:20]([NH:22][CH2:23][C:24]([NH:26][C@H:27]([C:35]([CH:37]1[C:44]2([NH2:46])[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:47][C:38]1([C:48]([O:50][CH3:51])=[O:49])[CH2:39]3)[CH2:43]2)=[O:36])[CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[O:25])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1Participants
3
Procedure
1.0 Gram of methyl L-tyrosyl-D-methionylglycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride in 100 ml of water is passed through this column at a rate of 1.0 ml/min. and the column is washed with an additional 100 ml of water. The combined eluates are lyophilized to give the acetate salt, methyl L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate acetic acid salt.
Workup
- washthe column is washed with an additional 100 ml of water
Sources & evidence
- ORD record
- ord-ec3da5bcd8be438286d82cc332f278c9
- Source dataset
- uspto-grants-1981_06
- Patent number
- US04273704
Reaction notes
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