HRID1680569

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C12CC3CC(CC(N)(C3)C1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C2.Cl

HCID70565529

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.COC(=O)C12CC3CC(CC(N)(C3)C1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C2

HCID70569102

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

1.0 Gram of methyl L-tyrosyl-D-methionylglycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride in 100 ml of water is passed through this column at a rate of 1.0 ml/min. and the column is washed with an additional 100 ml of water. The combined eluates are lyophilized to give the acetate salt, methyl L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate acetic acid salt.

WORKUP

后处理

washthe column is washed with an additional 100 ml of water

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ec3da5bcd8be438286d82cc332f278c9
来源数据集: uspto-grants-1981_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04273704
来源说明: uspto-grants-1981_06

反应 SMILES

Cl.[NH2:2][C@H:3]([C:12]([NH:14][C@@H:15]([C:20]([NH:22][CH2:23][C:24]([NH:26][C@H:27]([C:35]([CH:37]1[C:44]2([NH2:46])[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:47][C:38]1([C:48]([O:50][CH3:51])=[O:49])[CH2:39]3)[CH2:43]2)=[O:36])[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:25])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1>O>[C:48]([OH:50])(=[O:49])[CH3:38].[NH2:2][C@H:3]([C:12]([NH:14][C@@H:15]([C:20]([NH:22][CH2:23][C:24]([NH:26][C@H:27]([C:35]([CH:37]1[C:44]2([NH2:46])[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:47][C:38]1([C:48]([O:50][CH3:51])=[O:49])[CH2:39]3)[CH2:43]2)=[O:36])[CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[O:25])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1