HCID 12799294, compound → HCID 70569097, compound

Participants

Reaction Steps

Substitution of equivalent quantities of Boc-2,6-dimethyl-DL-tyrosyl-D-methionine and methyl glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride for the Boc-2,6-diemthyl-DL-tyrosine and methyl D-methioninate hydrochloride respectively of Example 35 and substantial repetition of the procedures described therein affords methyl Boc-2,6-dimethyl-DL-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate. When this compound is substituted for the methyl Boc-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate of Example 38 and the procedures described therein substantially repeated there is obtained methyl 2,6-dimethyl-DL-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride which is represented by the following formula ##STR42##

Provenance & Evidence