Phosphorus pentachloride → HCID 18371996, compound

HRID 1680610Notes

Reaction equation

HRID 1680610 reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[Br:12].P(Cl)(Cl)(Cl)(Cl)[Cl:14]>>[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][C:3]=1[Br:12]

Participants

3

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 119590494-amino-3,5-dibromobenzoic acid

Product 1

HCID 18371996HCID 18371996, compoundYield 73.4%

Procedure

In a flask equipped with a reflux condenser, 88.5 g (0.3 mole) of 4-amino-3,5-dibromobenzoic acid and 68 g (0.33 mole) of phosphorus pentachloride were reacted under reflux for one hour. After removal of phosphorus oxychloride under reduced pressure by means of an aspirator, the reaction product is subjected to vacuum distillation to obtain 69 g of 4-amino-3,5-dibromobenzoic acid chloride (yield: 73%).

Workup

  1. customIn a flask equipped with a reflux condenser
  2. temperatureunder reflux for one hour
  3. customAfter removal of phosphorus oxychloride under reduced pressure by means of an aspirator
  4. distillationthe reaction product is subjected to vacuum distillation

Sources & evidence

ORD record
ord-1e96e2e8c6614c60bded330f7650cff2
Source dataset
uspto-grants-1981_06
Patent number
US04274998

Reaction notes

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