Acetone → 3-Hydroxy-2-phenyl-5,6,7,8-tetrahydrothiazolo[2,3-b]benzothiazolium bromide

Participants

Reaction Steps

9.0 g. (0.053 moles) 2-mercapto-4,5,6,7-tetrahydrobenzothiazole and 10.75 g. (0.053 moles) α-bromophenylacetic acid are dissolved in 500 ml. of acetone, to which is further added 50 ml. each of glacial acetic acid and acetic anhydride. The mixture is heated in an open flask and the volume reduced to 100 ml. The precipitated solid is collected. The solid weighs 13 g. (67%) and melts at 233°-235° C.(dec.).

Provenance & Evidence