Dimethyl Sulfoxide → HCID 13020719, compound

Participants

Reaction Steps

Compound 6b (710 mg, 2 mmole) in CH2Cl2 (10 ml) was oxidized using DMSO (0.35 ml. 5 mmole) and trifluoroacetic anhydride (0.70 ml, 3.75 mmole) in methylene chloride (CH2Cl2) (8 ml) at -65° as described above. After the addition of TEA (1 ml), workup gave a residue which was purified by chromatography to give 474 mg (67%) of 7b as a glass whose structure was confirmed by NMR. This material was converted to the HCl salt which crystallized from methanol-ethyl acetate (MeOH-EtOAc) to give analytically pure 7b.HCl, mp 246°-248° which was confirmed by elemental analysis.

Provenance & Evidence