4-Toluenesulfonyl chloride → HCID 131712270, compound

Participants

Reaction Steps

3 g (10 mmols) of Glu-His-OH and 2.3 g of NaHCO3 are dissolved in 20 ml of water and, while stirring at room temperature, a solution of 2.1 g (10% excess) of p-toluene sulfochloride in about 10 ml of dioxane is slowly added drop by drop. When the addition is terminated, stirring of the mixture is continued for a further hour, whereupon it is extracted twice with ether. The aqueous phase is acidified to pH 2 with 2 N HCl and the precipitate is filtered off with suction. It is washed with water and the filer residue is dried over P2O5 under reduced pressure. Yield 2.2 g.

Provenance & Evidence