Tetrahydrofuran → HCID 23454741, compound

Participants

Reaction Steps

To the suspension of 9.3 g of lithium aluminumhydride in 200 ml of diethyl ether (anhydr.) is added dropwise the solution of 73.3 g of 1-(2-p-chlorophenyl-3-benzofuryl)-4-pelargonylpiperazine in the mixture of 500 ml of diethyl ether and 200 ml of tetrahydrofuran while stirring at 0°. After addition, the suspension is stirred at ambient temperature for 15 hours, then cooled again to 0° and successively combined with 9.3 ml of water, 9.3 ml of 15% aqueous sodium hydroxide and 27.9 ml of water. The suspension is stirred in the ice-bath for 1 hour, filtered and the residue washed with diethyl ether. The filtrate is dried, evaporated, the residue taken up in the minimum amount of isopropanol and the solution acidified with ethereal hydrogen chloride, to yield the 1-(2-p-chlorophenyl-3-benzofuryl)-4-n-nonylpiperazine hydrochloride melting at 268°-270° with decomposition.

Provenance & Evidence