HCID 23454749, compound → HCID 23454742, compound

Participants

Reaction Steps

The mixture of 13.5 g of 1-(5-benzyloxy-2-phenyl-3-benzofuryl)-4-methylpiperazine hydrochloride, 125 ml of ethanol and 2.5 g of 10% palladium on charcoal is hydrogenated at a pressure of 2.7 atm and at ambient temperature until the hydrogen uptake ceases. The catalyst is filtered off, the filtrate evaporated and the residue triturated with acetone to afford the crystalline 1-(5-hydroxy-2-phenyl-3-benzofuryl)-4-methylpiperazine hydrochloride monohydrate melting at 253°-256° with decomposition.

Provenance & Evidence