反应详情

4-Aminobutanol (2.7 g) and N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (4.05 g) were refluxed in ethanol (30 ml) for 4 hours. The reaction mixture was evaporated to yield an oil which was chromatographed on a silica gel column and eluted with chloroform and chloroform/methanol (20:1) to give the title compound as a colourless oil (1.8 g). (Found: C, 50.4; H, 7.4; N, 26.8; S, 10.1%. C13H22N6OS requires: C, 50.3; H, 7.2; N, 27.1; S, 10.3%). n.m.r. analysis in DMSO-d6 at 100 mHz:

1. customThe reaction mixture was evaporated
2. customto yield an oil which
3. customwas chromatographed on a silica gel column
4. washeluted with chloroform and chloroform/methanol (20:1)