Thionyl Chloride → HCID 13020595, compound

HRID 1680868Notes

Reaction equation

HRID 1680868 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11](O)[C:12]([CH3:17])([N+:14]([O-:16])=[O:15])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].S(Cl)([Cl:21])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]([Cl:21])[C:12]([CH3:17])([N+:14]([O-:16])=[O:15])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 13020594HCID 13020594, compound

Product 1

HCID 13020595HCID 13020595, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 6.2 g of 1-(3,4-dimethoxyphenyl)-2-methyl-2-nitropropanol, 3 ml of thionyl chloride and 40 ml of anhydrous benzene is refluxed for 4 hours. After the reaction, the reaction mixture is evaporated to remove solvent. The residue (dark brown oil) is distilled at 145° C. under reduced pressure (0.15 mm Hg). 4.6 g of 1-(3,4-dimethoxyphenyl)-1-chloro-2-methyl-2-nitropropane are thereby obtained as pale yellow prisms.

Workup

  1. temperatureis refluxed for 4 hours
  2. customAfter the reaction
  3. customthe reaction mixture is evaporated
  4. customto remove solvent
  5. distillationThe residue (dark brown oil) is distilled at 145° C. under reduced pressure (0.15 mm Hg)

Sources & evidence

ORD record
ord-37436b1a27384835be0b3628ae9f1edc
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

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