Ethanol → HCID 23454843, compound

HRID 1680872Notes

Reaction equation

HRID 1680872 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH:13](Cl)[C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15].C(O)C>[H][H].[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH2:13][C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15]

Participants

5

Reactant 2

HCID 702EthanolHCID 23454861HCID 23454861, compound

Product 1

HCID 23454843HCID 23454843, compoundYield 89.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 178418361HCID 178418361, compoundSolvent2×

Procedure

A mixture of 5 g of 1-(2,3,4-trimethoxyphenyl)-1-chloro-2-methyl-2-nitropropane, 2 g of 10% palladium-carbon and 50 ml of ethanol is shaken at room temperature in hydrogen gas atmosphere under atmospheric pressure. After the uptake of hydrogen is completed, insoluble materials are removed by filtration, and the filtrate is evaporated to remove solvent. 3.95 g of 1-(2,3,4-trimethoxyphenyl)-2-methyl-2-nitropropane are thereby obtained as a yellow oil.

Workup

  1. custominsoluble materials are removed by filtration
  2. customthe filtrate is evaporated
  3. customto remove solvent

Sources & evidence

ORD record
ord-ddfb208022fa4883b56f83618ba33158
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

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